These camelid sdAbs exhibited potent neutralizing activity against viruses expressing subtype B envelopes, including main viral isolates resistant to some bnAbs, including 2G12, b12, 2F5, 4E10, PG9, and PG16 (10)

These camelid sdAbs exhibited potent neutralizing activity against viruses expressing subtype B envelopes, including main viral isolates resistant to some bnAbs, including 2G12, b12, 2F5, 4E10, PG9, and PG16 (10). (CDR) regions, showing hydrophilic amino acids (Phe42, Glu49, Arg50, Gly52) in the FR2 region compared to standard human VH (Val42, Gly49, Leu50, Trp52). (B) Schematic … Continue reading These camelid sdAbs exhibited potent neutralizing activity against viruses expressing subtype B envelopes, including main viral isolates resistant to some bnAbs, including 2G12, b12, 2F5, 4E10, PG9, and PG16 (10)